Ppp2r1a^tm1.1Wltr
Targeted Allele Detail

Summary

• Symbol: Ppp2r1a^tm1.1Wltr
• Name: protein phosphatase 2, regulatory subunit A, alpha; targeted mutation 1.1, Gernot Walter
• MGI ID: MGI:5287252
• Synonyms: PP2A-A-alpha-floxed5-6 (F5-6)
• Gene: Ppp2r1a Location: Chr17:21165716-21186167 bp, + strand Genetic Position: Chr17, 11.4 cM, cytoband A3.2
• Alliance: Ppp2r1a^tm1.1Wltr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175748
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 5, and a frt-flanked neomycin resistance (neo) cassette followed by a second loxP site downstream of exon 6. Flp-mediated recombination removed the neo cassette. (J:175748)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppp2r1a Mutation: 41 strains or lines available

References

• Original: J:175748 Ruediger R, et al., Human Cancer-Associated Mutations in the A{alpha} Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A{alpha} Knock-In and Knockout Mice. Mol Cell Biol. 2011 Sep;31(18):3832-44
• All: 12 reference(s)