Ppp2r1a^tm2.1Wltr
Targeted Allele Detail

Summary

• Symbol: Ppp2r1a^tm2.1Wltr
• Name: protein phosphatase 2, regulatory subunit A, alpha; targeted mutation 2.1, Gernot Walter
• MGI ID: MGI:5287375
• Synonyms: PP2A-A-alpha-E64D
• Gene: Ppp2r1a Location: Chr17:21165716-21186167 bp, + strand Genetic Position: Chr17, 11.4 cM, cytoband A3.2
• Alliance: Ppp2r1a^tm2.1Wltr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175748
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 3 was related with a modified exon 3 in which nucleotide substitution (GAG to GAC) results in the amino acid substitution of aspartic acid for glutamic acid at position 64 (E64D), mimicking a mutation found in a human lung carcinoma. A floxed neo cassette inserted downstream of the modified exon 3 was removed by cre-mediated recombination. (J:175748)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp2r1a Mutation: 41 strains or lines available

References

• Original: J:175748 Ruediger R, et al., Human Cancer-Associated Mutations in the A{alpha} Subunit of Protein Phosphatase 2A Increase Lung Cancer Incidence in A{alpha} Knock-In and Knockout Mice. Mol Cell Biol. 2011 Sep;31(18):3832-44
• All: 2 reference(s)