Nfat5^tm1Skc
Targeted Allele Detail

Summary

• Symbol: Nfat5^tm1Skc
• Name: nuclear factor of activated T cells 5; targeted mutation 1, Sookja K Chung
• MGI ID: MGI:5287396
• Gene: Nfat5 Location: Chr8:108020102-108106149 bp, + strand Genetic Position: Chr8, 53.93 cM, cytoband D2
• Alliance: Nfat5^tm1Skc page

Peripheral edema in E14.5 Nfat5^tm1Skc/Nfat5^tm1Skc embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175527
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Parts of exons 5 and 6 were replaced with a pgk-neo cassette via homologous recombination. RT-PCR confirms the absence of expression in the hearts of homozygous mice at E14.5. (J:175527)

Targeting vector to generate the Nfat5^tm1Skc allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfat5 Mutation: 67 strains or lines available

References

• Original: J:175527 Mak MC, et al., Embryonic lethality in mice lacking the nuclear factor of activated T cells 5 protein due to impaired cardiac development and function. PLoS One. 2011;6(7):e19186
• All: 3 reference(s)