Hoxa1^tm8.2Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxa1^tm8.2Mrc
• Name: homeobox A1; targeted mutation 8.2, Mario R Capecchi
• MGI ID: MGI:5287662
• Synonyms: Hoxa1^delta
• Gene: Hoxa1 Location: Chr6:52132573-52135299 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa1^tm8.2Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175781
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and EcoRI siter were inserted 200 bp upstream of the transcription initiation site and a loxP site, EcoRI site, and FRT flanked neo cassette were inserted36 bp downstream of the stop codon via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exons 1 and 2. (J:175781)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa1 Mutation: 14 strains or lines available

References

• Original: J:175781 Makki N, et al., Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Dev Biol. 2011 Sep 15;357(2):295-304
• All: 1 reference(s)