Ndrg4^tm1Myta
Targeted Allele Detail

Summary

• Symbol: Ndrg4^tm1Myta
• Name: N-myc downstream regulated gene 4; targeted mutation 1, Toshiyuki Miyata
• MGI ID: MGI:5287887
• Gene: Ndrg4 Location: Chr8:96403602-96441584 bp, + strand Genetic Position: Chr8, 47.12 cM
• Alliance: Ndrg4^tm1Myta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175573
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An inverted floxed pST-neoB cassette was inserted into exon 6 via homologous recombination. Western blot analysis confirmed the absence of expression of all protein isoforms in the brains of homozygous mice. (J:175573)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndrg4 Mutation: 19 strains or lines available

References

• Original: J:175573 Yamamoto H, et al., NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia. J Biol Chem. 2011 Jul 22;286(29):26158-65
• All: 1 reference(s)