Lmx1atm1Ics
Targeted Allele Detail
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Symbol: |
Lmx1atm1Ics |
Name: |
LIM homeobox transcription factor 1 alpha; targeted mutation 1, Mouse Clinical Institute |
MGI ID: |
MGI:5287977 |
Synonyms: |
Lmx1aeGFP |
Gene: |
Lmx1a Location: Chr1:167516806-167676310 bp, + strand Genetic Position: Chr1, 75.08 cM
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Alliance: |
Lmx1atm1Ics page
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Germline Transmission: |
Earliest citation of germline transmission:
J:175535
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A genomic fragment, including exons 1and 2, intron 1 and part of intron 2, was replaced with an EGFP gene and a floxed neo cassette via homologous recombination. In heterozygous mice EGFP expression recapitulates endogenous gene expression. Immunohistochemical analysis confirmed the absence of wild-type protein expression in the ventral midbrain of homozygous embryos at E11.5.
(J:175535)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lmx1a Mutation: |
21 strains or lines available
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Original: |
J:175535 Deng Q, et al., Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development. 2011 Aug;138(16):3399-408 |
All: |
4 reference(s) |
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