Lmx1a^tm1.1Tpe
Targeted Allele Detail

Summary

• Symbol: Lmx1a^tm1.1Tpe
• Name: LIM homeobox transcription factor 1 alpha; targeted mutation 1.1, Thomas Perlmann
• MGI ID: MGI:5287979
• Synonyms: Lmx1a^-
• Gene: Lmx1a Location: Chr1:167516806-167676310 bp, + strand Genetic Position: Chr1, 75.08 cM
• Alliance: Lmx1a^tm1.1Tpe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175535
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1and a floxed neo cassette was inserted 288 bp downstream of exon 2 via homologous recombination. Cre mediated recombination deleted exons 1and 2, intron 1 and part of intron 2. Immunohistochemical analysis confirmed the absence of wild-type protein expression in the ventral midbrain of homozygous embryos at E11.5. (J:175535)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmx1a Mutation: 21 strains or lines available

References

• Original: J:175535 Deng Q, et al., Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development. 2011 Aug;138(16):3399-408
• All: 1 reference(s)