Dcdc2a^tm1.2Jjlo
Targeted Allele Detail

Summary

• Symbol: Dcdc2a^tm1.2Jjlo
• Name: doublecortin domain containing 2a; targeted mutation 1.2, Joseph J LoTurco
• MGI ID: MGI:5288003
• Synonyms: Dcdc2^del2
• Gene: Dcdc2a Location: Chr13:25239987-25394689 bp, + strand Genetic Position: Chr13, 10.89 cM
• Alliance: Dcdc2a^tm1.2Jjlo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175635
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exon 2. Quantitative real time PCR showed that expression levels are about 10 fold lower in homozygous mice compared to wild-type mice. (J:175635)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dcdc2a Mutation: 50 strains or lines available

References

• Original: J:175635 Wang Y, et al., Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin. Neuroscience. 2011 Sep 8;190:398-408
• All: 5 reference(s)