Bcl2^tm2.1Lbox
Targeted Allele Detail

Summary

• Symbol: Bcl2^tm2.1Lbox
• Name: B cell leukemia/lymphoma 2; targeted mutation 2.1, Linda M Boxer
• MGI ID: MGI:5288478
• Synonyms: IgH-3'E-bcl2
• Gene: Bcl2 Location: Chr1:106465908-106642004 bp, - strand Genetic Position: Chr1, 49.76 cM
• Alliance: Bcl2^tm2.1Lbox page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175730
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The IgH 3' enhancer (normally located 170 kb from the promoter) with a floxed neo cassette was inserted downstream of the untranslated region. This insertion mimics the t(14;18) chromosomal translocation associated with human follicular B-cell lymphoma. Cre-mediated recombination removed the neo cassette. Protein expression is increased 3.5- to 5.5-fold. (J:175730)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2 Mutation: 41 strains or lines available

References

• Original: J:175730 Xiang H, et al., The immunoglobulin heavy chain gene 3' enhancers induce Bcl2 deregulation and lymphomagenesis in murine B cells. Leukemia. 2011 Sep;25(9):1484-93
• All: 1 reference(s)