Cd101^tm1.1Dil
Targeted Allele Detail

Summary

• Symbol: Cd101^tm1.1Dil
• Name: CD101 antigen; targeted mutation 1.1, Linda Wicker
• MGI ID: MGI:5288503
• Gene: Cd101 Location: Chr3:100900845-100936872 bp, - strand Genetic Position: Chr3, 43.9 cM
• Alliance: Cd101^tm1.1Dil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175943
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the neo cassette. The absence of protein expression was confirmed by cell sorting on bone marrow and spleen cells. (J:175943)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd101 Mutation: 47 strains or lines available

References

• Original: J:175943 Rainbow DB, et al., Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. J Immunol. 2011 Jul 1;187(1):325-36
• All: 2 reference(s)