Mterf4^tm1.2Lrsn
Targeted Allele Detail

Summary

• Symbol: Mterf4^tm1.2Lrsn
• Name: mitochondrial transcription termination factor 4; targeted mutation 1.2, Nils-Goran Larsson
• MGI ID: MGI:5288506
• Synonyms: Mterf4^-
• Gene: Mterf4 Location: Chr1:93228927-93233601 bp, - strand Genetic Position: Chr1, 47.24 cM, cytoband D
• Alliance: Mterf4^tm1.2Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175816
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 2 and a second loxP site was inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exon 2. (J:175816)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mterf4 Mutation: 14 strains or lines available

References

• Original: J:175816 Camara Y, et al., MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metab. 2011 May 4;13(5):527-39
• All: 1 reference(s)