Zfp42^tm1.1Log
Targeted Allele Detail

Summary

• Symbol: Zfp42^tm1.1Log
• Name: zinc finger protein 42; targeted mutation 1.1, Lorraine J Gudas
• MGI ID: MGI:5289943
• Gene: Zfp42 Location: Chr8:43748100-43760017 bp, - strand Genetic Position: Chr8, 23.89 cM
• Alliance: Zfp42^tm1.1Log page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175380
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo and thymidine kinase cassette was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the neo-tk cassette and exon 4. The absence of protein expression was confirmed by western blot analysis on testicular extracts. (J:175380)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp42 Mutation: 44 strains or lines available

References

• Original: J:175380 Rezende NC, et al., Rex1 (Zfp42) null mice show impaired testicular function, abnormal testis morphology, and aberrant gene expression. Dev Biol. 2011 Aug 15;356(2):370-82
• All: 1 reference(s)