Tg(tetO-SNCA)7Vle
Transgene Detail
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| Symbol: |
Tg(tetO-SNCA)7Vle |
| Name: |
transgene insertion 7, Virginia M-Y Lee |
| MGI ID: |
MGI:5289965 |
| Synonyms: |
tetP-WTapha-syn |
| Transgene: |
Tg(tetO-SNCA)7Vle Location: unknown
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| Alliance: |
Tg(tetO-SNCA)7Vle page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inducible, Inserted expressed sequence) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Mutation details: This transgene consists of the human wild-type alpha-synuclein cDNA under the control of the tetracycline responsive promoter. Alpha-synuclein is expressed only in the presence of the tetracycline transactivator (tTA), expressed from a second transgene; administration of doxycycline inhibits tTA binding to tetO, thus suppressing alpha-synuclein expression.
(J:156801)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:156801 Lim Y, et al., Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Exp Neurol. 2010 Jan;221(1):86-97 |
| All: |
2 reference(s) |
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Analysis Tools
