Vldlr^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Vldlr^m1Btlr
• Name: very low density lipoprotein receptor; mutation 1, Bruce Beutler
• MGI ID: MGI:5290092
• Synonyms: r26
• Gene: Vldlr Location: Chr19:27193884-27231631 bp, + strand Genetic Position: Chr19, 21.77 cM
• Alliance: Vldlr^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at position 27320144 bp of the genomic sequence of Vldlr, affecting nucleotide 2239 of the mRNA in exon 15 (NCBI RefSeq: (NM_013703.2), Variant 1; NM_001161420.1, variant 2). The mutation results in coding of a premature stop codon after amino acid 746 (R747*). (J:176337)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vldlr Mutation: 69 strains or lines available

References

• Original: J:176337 Xia CH, et al., The role of Vldlr in intraretinal angiogenesis in mice. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6572-9
• All: 2 reference(s)