Tnfaip3^tm1.1Awai
Targeted Allele Detail

Summary

• Symbol: Tnfaip3^tm1.1Awai
• Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 1.1, Ari Waisman
• MGI ID: MGI:5291646
• Synonyms: A20^fl
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^tm1.1Awai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175422
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette leaving exon 3 floxed. (J:175422)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 45 strains or lines available

References

• Original: J:175422 Hovelmeyer N, et al., A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies. Eur J Immunol. 2011 Mar;41(3):595-601
• All: 5 reference(s)