Pax3^{tm6.1(Pax8)Buck}
Targeted Allele Detail

Summary

• Symbol: Pax3^{tm6.1(Pax8)Buck}
• Name: paired box 3; targeted mutation 6.1, Margaret E Buckingham
• MGI ID: MGI:5291822
• Synonyms: Pax3^Pax8-ILZ, Pax3^{Pax8-IRES-nlacZ}
• Gene: Pax3 Location: Chr1:78077904-78173771 bp, - strand Genetic Position: Chr1, 39.79 cM
• Alliance: Pax3^{tm6.1(Pax8)Buck} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176192
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Cre-mediated recombination removed the EGFP and puro cassettes. The Pax8, IRES, and nuclear localized lacZ remain intact within intron 1. Expression of Pax3 is replaced with expression of Pax8. (J:176192)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax3 Mutation: 50 strains or lines available

References

• Original: J:176192 Hayashi S, et al., Lack of In Vivo Functional Compensation Between Pax Family Groups II and III in Rodents. Mol Biol Evol. 2011 Oct;28(10):2787-98
• All: 1 reference(s)