Pax3^tm6.2Buck
Targeted Allele Detail

Summary

• Symbol: Pax3^tm6.2Buck
• Name: paired box 3; targeted mutation 6.2, Margaret E Buckingham
• MGI ID: MGI:5291823
• Synonyms: Pax3^EGFP8
• Gene: Pax3 Location: Chr1:78077904-78173771 bp, - strand Genetic Position: Chr1, 39.79 cM
• Alliance: Pax3^tm6.2Buck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176192
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Flp-mediated recombination removed the puro cassette, loxP site, Pax8 cDNA, and IRES-nlacZ. A single loxP site, EGFP gene, and FRT site remain in intron 1. (J:176192)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax3 Mutation: 50 strains or lines available

References

• Original: J:176192 Hayashi S, et al., Lack of In Vivo Functional Compensation Between Pax Family Groups II and III in Rodents. Mol Biol Evol. 2011 Oct;28(10):2787-98
• All: 3 reference(s)