Ptpmt1^tm1.2Jedi
Targeted Allele Detail

Summary

• Symbol: Ptpmt1^tm1.2Jedi
• Name: protein tyrosine phosphatase, mitochondrial 1; targeted mutation 1.2, Jack E Dixon
• MGI ID: MGI:5291922
• Gene: Ptpmt1 Location: Chr2:90741057-90748395 bp, - strand Genetic Position: Chr2, 50.44 cM, cytoband E1
• Alliance: Ptpmt1^tm1.2Jedi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176087
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and exons 1 and 2. (J:176087)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpmt1 Mutation: 14 strains or lines available

References

• Original: J:176087 Zhang J, et al., Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011 Jun 8;13(6):690-700
• All: 1 reference(s)