Cacna1c^tm4Hfm
Targeted Allele Detail

Summary

• Symbol: Cacna1c^tm4Hfm
• Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 4, Franz Hofmann
• MGI ID: MGI:5291981
• Synonyms: Cav1.2^I1624E
• Gene: Cacna1c Location: Chr6:118564201-119173851 bp, - strand Genetic Position: Chr6, 55.86 cM
• Alliance: Cacna1c^tm4Hfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175463
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Not Specified) Mutations: Insertion, Nucleotide substitutions Mutation details: A floxed neo cassette was inserted upstream of a modified exon 40 in which nucleotide substitutions (ATC to GAG) results in the amino acid substitution of glutamic acid for isoleucine at position 1624 (I1624E). (J:175463)

Generation of the Cacna1c^tm4Hfm allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1c Mutation: 144 strains or lines available

References

• Original: J:175463 Poomvanicha M, et al., Facilitation and Ca2+-dependent inactivation are modified by mutation of the Ca(v)1.2 channel IQ motif. J Biol Chem. 2011 Jul 29;286(30):26702-7
• All: 2 reference(s)