Nrg1^tm1Sabe
Targeted Allele Detail

Summary

• Symbol: Nrg1^tm1Sabe
• Name: neuregulin 1; targeted mutation 1, Shin-ichi Abe
• MGI ID: MGI:5292107
• Synonyms: Nrg1^loxP
• Gene: Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
• Alliance: Nrg1^tm1Sabe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175448
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. A neo cassette with a 5' loxP site was inserted downstream of exon 6. (J:175448)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg1 Mutation: 54 strains or lines available

References

• Original: J:175448 Zhang J, et al., Neuregulins are essential for spermatogonial proliferation and meiotic initiation in neonatal mouse testis. Development. 2011 Aug;138(15):3159-68
• All: 4 reference(s)