Tctn2^tm1.1Reit
Targeted Allele Detail

Summary

• Symbol: Tctn2^tm1.1Reit
• Name: tectonic family member 2; targeted mutation 1.1, Jeremy Reiter
• MGI ID: MGI:5292130
• Gene: Tctn2 Location: Chr5:124736812-124765803 bp, + strand Genetic Position: Chr5, 63.68 cM, cytoband F
• Alliance: Tctn2^tm1.1Reit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173396
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. A floxed puro cassette was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and exons 1 through 3. (J:173396)

Expression

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tctn2 Mutation: 22 strains or lines available

Notes

The allele was originally generated in ES cells containing Tctn1^{Gt(KST296)Byg}.

References

• Original: J:173396 Sang L, et al., Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell. 2011 May 13;145(4):513-28
• All: 5 reference(s)