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Tg(KRT5-rtTA)T2D6Sgkd
Transgene Detail
Summary
Symbol: Tg(KRT5-rtTA)T2D6Sgkd
Name: transgene insertion T2D6, Silvio Gutkind
MGI ID: MGI:5292234
Synonyms: K5-rtTa
Transgene: Tg(KRT5-rtTA)T2D6Sgkd  Location: unknown  
Alliance: Tg(KRT5-rtTA)T2D6Sgkd page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
 
Mutation detailsThe K5-rtTA transgene was designed with a bovine keratin 5 (KRT5) promoter driving expression of the reverse tetracycline transactivator gene (rtTA) with a nuclear localization signal (nls), followed by a polyadenylation signal. Line T2D6 was generated. (J:94955)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:94955 Vitale-Cross L, et al., Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis. Cancer Res. 2004 Dec 15;64(24):8804-7
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory