Tg(A930038C07Rik-cre)1Aibs
Transgene Detail

Summary

• Symbol: Tg(A930038C07Rik-cre)1Aibs
• Name: transgene insertion 1, Allen Institute for Brain Science
• MGI ID: MGI:5292251
• Synonyms: A930038C07Rik-Tg1-Cre
• Transgene: Tg(A930038C07Rik-cre)1Aibs Location: unknown
• Alliance: Tg(A930038C07Rik-cre)1Aibs page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1 x C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(A930038C07Rik-cre)1Aibs expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ndnf (MGI:1915419)

• Mutation details: The 196 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-476E22, containing the entire A930038C07Rik locus (and other genes), was modified by targeting a Cre recombinase coding sequence, SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the A930038C07Rik locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. The resulting modified BAC was microinjected into embryos from B6C3 mice ((C57BL/6 x C3H)F1 X C57BL/6). Mice from founder line A930038C07Rik-Tg1-Cre were bred to C57BL/6J mice to generate the colony. Detection of cre mRNA by in situ hybridization in adult mice is reported to be specific to layer 5 (Layer 5B) cortical cells corresponding to thick-tufted pyramidal neurons. Reporter activity in crosses to cre reporter mice is more widespread, presumably due to cre activity during development. This line demonstrates a much more specific expression pattern compared to mice from founder line 4 (Tg(A930038C07Rik-cre)1Aibs). (J:146821)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ndnf (mouse) Summary of all recombinase alleles driven by Ndnf. Alliance mouse Ndnf gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:146821 Allen Institute for Brain Science, Cre transgenes and knockin alleles created at the Allen Insitute for Brain Science (AIBS). MGI Direct Data Submission. 2009-04-06
• All: 9 reference(s)