Grin2atm1.1Ppao
Targeted Allele Detail
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Symbol: |
Grin2atm1.1Ppao |
Name: |
glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1.1, Pierre Paoletti |
MGI ID: |
MGI:5292331 |
Synonyms: |
NR2A-H128S, NR2AH128S |
Gene: |
Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
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Alliance: |
Grin2atm1.1Ppao page
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Germline Transmission: |
Earliest citation of germline transmission:
J:175900
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exon 1 was replaced with a modified exon 1 in which nucleotide substitutions (CAT to TCC) result in the amino acid substitution of serine for histidine at position 128 (H128S). A floxed neo cassette inserted downstream of the modified exon 1 was removed by cre-mediated recombination.
(J:175900)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Grin2a Mutation: |
66 strains or lines available
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Original: |
J:175900 Nozaki C, et al., Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit. Nat Neurosci. 2011 Aug;14(8):1017-22 |
All: |
3 reference(s) |
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