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Grin2atm1.1Ppao
Targeted Allele Detail
Summary
Symbol: Grin2atm1.1Ppao
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1.1, Pierre Paoletti
MGI ID: MGI:5292331
Synonyms: NR2A-H128S, NR2AH128S
Gene: Grin2a  Location: Chr16:9385762-9813424 bp, - strand  Genetic Position: Chr16, 5.28 cM
Alliance: Grin2atm1.1Ppao page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175900
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 1 was replaced with a modified exon 1 in which nucleotide substitutions (CAT to TCC) result in the amino acid substitution of serine for histidine at position 128 (H128S). A floxed neo cassette inserted downstream of the modified exon 1 was removed by cre-mediated recombination. (J:175900)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grin2a Mutation:  66 strains or lines available
References
Original:  J:175900 Nozaki C, et al., Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit. Nat Neurosci. 2011 Aug;14(8):1017-22
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory