Drd2^tm1.1Mrub
Targeted Allele Detail

Summary

• Symbol: Drd2^tm1.1Mrub
• Name: dopamine receptor D2; targeted mutation 1.1, Marcelo Rubinstein
• MGI ID: MGI:5292350
• Synonyms: Drd2^loxP
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^tm1.1Mrub page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176167
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed the floxed neo cassette inserted downstream of exon 2. (J:176167)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:176167 Bello EP, et al., Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors. Nat Neurosci. 2011 Aug;14(8):1033-8
• All: 43 reference(s)