Inca1^tm1Cmt
Targeted Allele Detail

Summary

• Symbol: Inca1^tm1Cmt
• Name: inhibitor of CDK, cyclin A1 interacting protein 1; targeted mutation 1, Carsten Muller-Tidow
• MGI ID: MGI:5292392
• Gene: Inca1 Location: Chr11:70579187-70590981 bp, - strand Genetic Position: Chr11, 43.21 cM
• Alliance: Inca1^tm1Cmt page

Disruption of splenic architecture in Inca1^tm1Cmt/Inca1^tm1Cmt mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175667
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Exons 3 through 7 were replaced with an IRES, lacZ, and floxed neo cassette. The absence of transcript expression was confirmed by RT-PCR on mouse embryonic fibroblasts, testis, liver, kidney, and lung extracts. (J:175667)

Generation of the Inca1^tm1Cmt allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Inca1 Mutation: 15 strains or lines available

References

• Original: J:175667 Baumer N, et al., Inhibitor of Cyclin-dependent Kinase (CDK) Interacting with Cyclin A1 (INCA1) Regulates Proliferation and Is Repressed by Oncogenic Signaling. J Biol Chem. 2011 Aug 12;286(32):28210-22
• All: 3 reference(s)