Gcm2^tm1Hoso
Targeted Allele Detail

Summary

• Symbol: Gcm2^tm1Hoso
• Name: glial cells missing homolog 2; targeted mutation 1, Toshihiko Hosoya
• MGI ID: MGI:5292469
• Gene: Gcm2 Location: Chr13:41254903-41264511 bp, - strand Genetic Position: Chr13, 20.31 cM
• Alliance: Gcm2^tm1Hoso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175891
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence for the GCM motif was replaced with an IRES, lacZ, and floxed neo cassette. Due to a frame shift, no beta-galactosidase activity is detected. (J:175891)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcm2 Mutation: 34 strains or lines available

References

• Original: J:175891 Hitoshi S, et al., Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells. Nat Neurosci. 2011 Aug;14(8):957-64
• All: 1 reference(s)