Tcrb^tm9.1Slek
Targeted Allele Detail

Summary

• Symbol: Tcrb^tm9.1Slek
• Name: T cell receptor beta chain; targeted mutation 9.1, Barry P Sleckman
• MGI ID: MGI:5292493
• Synonyms: Tcrb^F
• Gene: Tcrb Location: Chr6:40868230-41535305 bp, + strand Genetic Position: Chr6, cytoband A-C

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176070
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted Mutation: Intragenic deletion Mutation details: Multi-step targeting deleted Db1, replaced Db2, Jb2.1, Jb2.2, and Jb2.3 with DJb2.3, and replaced the four Cb2 exons with a cDNA fusion of those exons. Cre-mediated recombination removed the floxed neo cassette downstream of Cb2. (J:176070)

Targeting strategy for generating the Tcrb^tm9.1Slek allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcrb Mutation: 97 strains or lines available

References

• Original: J:176070 Mahowald GK, et al., Out-of-frame T cell receptor beta transcripts are eliminated by multiple pathways in vivo. PLoS One. 2011;6(7):e21627
• All: 1 reference(s)