Gt(ROSA)26Sor^tm1.1Lrsn
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1.1Lrsn
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Nils-Goran Larsson
• MGI ID: MGI:5292497
• Synonyms: Gt(ROSA26)Sor^mito-YFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1.1Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176022
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutation: Insertion Mutation details: Cre-mediated recombination removed the floxed stop cassette and allowed for the ubiquitous expression of the mitochondrial targeted YFP. (J:176022)

Design of lox-Stop-lox-mito-YFP and targeting to the ROSA26 locus to generate the Gt(ROSA)26Sor^tm1Lrsn and Gt(ROSA)26Sor^tm1.1Lrsn alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:176022 Sterky FH, et al., Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12937-42
• All: 1 reference(s)