Tet1^tm1.1Jae
Targeted Allele Detail

Summary

• Symbol: Tet1^tm1.1Jae
• Name: tet methylcytosine dioxygenase 1; targeted mutation 1.1, Rudolf Jaenisch
• MGI ID: MGI:5292563
• Gene: Tet1 Location: Chr10:62640349-62723242 bp, - strand Genetic Position: Chr10, 32.48 cM
• Alliance: Tet1^tm1.1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175858
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector containing a FRT site flanked neo cassette with a downstream loxP site was inserted upstream of exon 5. A second loxP site was inserted upstream of exon 4. Cre-mediated recombination removed the neo cassette and exon 4. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:175858)

Expression

In Mice Carrying this Mutation:	2 assay results 7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tet1^tm1.1Jae

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tet1 Mutation: 143 strains or lines available

References

• Original: J:175858 Dawlaty MM, et al., Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell. 2011 Aug 5;9(2):166-75
• All: 37 reference(s)