Irag1^tm2.1Jens
Targeted Allele Detail

Summary

• Symbol: Irag1^tm2.1Jens
• Name: inositol 1,4,5-triphosphate receptor associated 1; targeted mutation 2.1, Jens Schlossmann
• MGI ID: MGI:5292572
• Synonyms: IRAG^L1
• Gene: Irag1 Location: Chr7:110467473-110581668 bp, - strand Genetic Position: Chr7, 57.9 cM
• Alliance: Irag1^tm2.1Jens page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175887
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was flanked with a floxed neo cassette and an additional loxP site. Cre-mediated recombination removed the neo cassette and exon 3. The absence of protein expression was confirmed by western blot analysis on aorta or colon extracts. (J:175587)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irag1 Mutation: 51 strains or lines available

References

• Original: J:175887 Desch M, et al., IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation. Cardiovasc Res. 2010 Jun 1;86(3):496-505
• All: 5 reference(s)