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Tcf7l2em1Nobr
Endonuclease-mediated Allele Detail
Summary
Symbol: Tcf7l2em1Nobr
Name: transcription factor 7 like 2, T cell specific, HMG box; endonuclease-mediated mutation 1, Marcelo A Nobrega
MGI ID: MGI:5292672
Synonyms: Line 1
Gene: Tcf7l2  Location: Chr19:55730252-55922086 bp, + strand  Genetic Position: Chr19, 51.59 cM
Alliance: Tcf7l2em1Nobr page
Mutation
origin
Strain of Origin:  CD-1
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA zinc finger targeting exon 11 (using alternative exon 4 in exon numbering) induced a 1 bp deletion that results in alteration of the amino acids after codon 390 (TLAGLHGITMGRRRREKETSSRGKPTNTANVS) and introduction of a premature stop codon. (J:175874)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7l2 Mutation:  58 strains or lines available
References
Original:  J:175874 Savic D, et al., Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res. 2011 Sep;21(9):1417-25
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory