Tcf7l2^em2Nobr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tcf7l2^em2Nobr
• Name: transcription factor 7 like 2, T cell specific, HMG box; endonuclease-mediated mutation 2, Marcelo A Nobrega
• MGI ID: MGI:5292673
• Synonyms: Line 2
• Gene: Tcf7l2 Location: Chr19:55730252-55922086 bp, + strand Genetic Position: Chr19, 51.59 cM
• Alliance: Tcf7l2^em2Nobr page

Mutation origin

• Strain of Origin: CD-1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A zinc finger targeting exon 11 (using alternative exon 4 in exon numbering) induced a 1 bp deletion that alternate the amino acids sequence after codon 390 (SLAGLHGITMGRRRREKETSSRGKPTNTANVS) and introduction of a premature stop codon. (J:175874)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7l2 Mutation: 58 strains or lines available

References

• Original: J:175874 Savic D, et al., Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res. 2011 Sep;21(9):1417-25
• All: 3 reference(s)