Nr5a1^tm1.1Hain
Targeted Allele Detail

Summary

• Symbol: Nr5a1^tm1.1Hain
• Name: nuclear receptor subfamily 5, group A, member 1; targeted mutation 1.1, Holly A Ingraham
• MGI ID: MGI:5292676
• Synonyms: Sf-1^2KR
• Gene: Nr5a1 Location: Chr2:38582668-38604554 bp, - strand Genetic Position: Chr2, 24.42 cM
• Alliance: Nr5a1^tm1.1Hain page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175843
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The 2 SUMO consensus sites (K119 and K194) in exon 3 were mutated to arginine (R) residues and a floxed neo cassette was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the neo cassette. Tissues in homozygous mice showed a pronounced loss of sumoylated protein species. (J:175843)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr5a1 Mutation: 30 strains or lines available

References

• Original: J:175843 Lee FY, et al., Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Dev Cell. 2011 Aug 16;21(2):315-27
• All: 2 reference(s)