Capn2^tm1Tcs
Targeted Allele Detail

Summary

• Symbol: Capn2^tm1Tcs
• Name: calpain 2; targeted mutation 1, Takaomi C Saido
• MGI ID: MGI:5292734
• Synonyms: Capn2^-
• Gene: Capn2 Location: Chr1:182294825-182345173 bp, - strand Genetic Position: Chr1, 84.93 cM
• Alliance: Capn2^tm1Tcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175868
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 3 to 7 were replaced with a pgk-neo cassette via homologous recombination. (J:175868)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Capn2 Mutation: 35 strains or lines available

References

• Original: J:175868 Takano J, et al., Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol. 2011 Oct;31(19):4097-106
• All: 1 reference(s)