Capn2^tm2.1Tcs
Targeted Allele Detail

Summary

• Symbol: Capn2^tm2.1Tcs
• Name: calpain 2; targeted mutation 2.1, Takaomi C Saido
• MGI ID: MGI:5292735
• Synonyms: Capn2^flox
• Gene: Capn2 Location: Chr1:182294825-182345173 bp, - strand Genetic Position: Chr1, 84.93 cM
• Alliance: Capn2^tm2.1Tcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175868
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 3 and a loxP site was inserted downstream of exon 3 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 3 floxed. (J:175868)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Capn2 Mutation: 35 strains or lines available

References

• Original: J:175868 Takano J, et al., Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival. Mol Cell Biol. 2011 Oct;31(19):4097-106
• All: 4 reference(s)