Foxo6^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Foxo6^{tm1(KOMP)Vlcg}
• Name: forkhead box O6; targeted mutation 1, Velocigene
• MGI ID: MGI:5292882
• Synonyms: FoxO6-KO
• Gene: Foxo6 Location: Chr4:120124275-120144458 bp, - strand Genetic Position: Chr4, 56.1 cM
• Alliance: Foxo6^{tm1(KOMP)Vlcg} page
• IMPC: Foxo6 gene page

Mutation origin

• Mutant Cell Lines: 12465B-E5, 12465B-F6, 12465B-F9
• Germline Transmission: Earliest citation of germline transmission: J:236585
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 19436bp between positions 120125011-120144446 of Chromosome 4 (Build GRCm39). qRT-PCR analysis confirmed the absence of mRNA expression in the liver of homozygous mutant mice. (J:136110, J:236585)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Foxo6 Mutation: 12 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 3 reference(s)