Selenof^tm1Vgla
Targeted Allele Detail

Summary

• Symbol: Selenof^tm1Vgla
• Name: selenoprotein F; targeted mutation 1, Vadim N Gladyshev
• MGI ID: MGI:5293082
• Gene: Selenof Location: Chr3:144276188-144303438 bp, + strand Genetic Position: Chr3, 68.94 cM, cytoband H3
• Alliance: Selenof^tm1Vgla page

Selenof^tm1Vgla/Selenof^tm1Vgla mice develop cataracts

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176744
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 was replaced with a neo cassette. The abscence of protein expression was confirmed by western blot analysis on mouse embryonic extracts. (J:176744)

Generation of the Selenof^tm1Vgla allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Selenof Mutation: 21 strains or lines available

References

• Original: J:176744 Kasaikina MV, et al., Roles of the 15-kDa Selenoprotein (Sep15) in Redox Homeostasis and Cataract Development Revealed by the Analysis of Sep 15 Knockout Mice. J Biol Chem. 2011 Sep 23;286(38):33203-12
• All: 4 reference(s)