Apba3^tm1.2Ski
Targeted Allele Detail

Summary

• Symbol: Apba3^tm1.2Ski
• Name: amyloid beta precursor protein binding family A member 3; targeted mutation 1.2, Motoharu Seiki
• MGI ID: MGI:5293147
• Gene: Apba3 Location: Chr10:81102799-81109081 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Apba3^tm1.2Ski page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176742
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed exons 2 and 3 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain, liver, kidney, and muscle extract. (J:176742)

Generation of the Apba3^tm1.2Ski allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apba3 Mutation: 22 strains or lines available

References

• Original: J:176742 Hara T, et al., Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock. J Biol Chem. 2011 Sep 16;286(37):32542-51
• All: 5 reference(s)