Tg(Acta2-cre)#Xya
Transgene Detail

Summary

• Symbol: Tg(Acta2-cre)#Xya
• Name: transgene insertion, Xiao Yang
• MGI ID: MGI:5293230
• Synonyms: alpha-SMA-Cre
• Transgene: Tg(Acta2-cre)#Xya Location: unknown
• Alliance: Tg(Acta2-cre)#Xya page

Transgene origin

• Strain of Origin: CBA

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Acta2-cre)#Xya expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Acta2

• Mutation details: The transgenic vector contained the cre recombinase sequence and a neo/polyadenylation sequences inserted behind an Acta2 (alpha smooth muscle actin) promoter fragment (from -1010 to about +2582, including exon 1 and part of intron 1 referred to as SMP8). The construct was injected into fertilized F2 eggs from CBA mice. Four founders were obtained and two mice were chosen and crossed to reporter mice, demonstrating smooth muscle-specific cre activity. Line numbers were not indicated. (J:176490)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Acta2 (species not specified) Summary of all recombinase alleles driven by Acta2.

Expression

In Mice Carrying this Mutation:

72 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:176490 Wu Z, et al., Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir Res. 2007;8:1
• All: 22 reference(s)