Capns1^tm1.1Otsu
Targeted Allele Detail

Summary

• Symbol: Capns1^tm1.1Otsu
• Name: calpain, small subunit 1; targeted mutation 1.1, Kinya Otsu
• MGI ID: MGI:5293309
• Synonyms: Capns1^flox
• Gene: Capns1 Location: Chr7:29886361-29898236 bp, - strand Genetic Position: Chr7, 17.31 cM
• Alliance: Capns1^tm1.1Otsu page

Increased cardiac fibrosis in Capns1^tm1.1Otsu/Capns1^tm1.1Otsu Tg(Myh6-cre)2182Mds/0 mice after transverse aortic constriction

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176736
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 7. A floxed neo cassette was inserted downstream of exon 9. Cre-mediated recombination removed the neo cassette and left exons 7 through 9 floxed. (J:176736)

Creation of the conditional Capns1^tm1.1Otsu allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Capns1 Mutation: 34 strains or lines available

References

• Original: J:176736 Taneike M, et al., Calpain protects the heart from hemodynamic stress. J Biol Chem. 2011 Sep 16;286(37):32170-7
• All: 1 reference(s)