Col10a1^tm1(cre)Haak
Targeted Allele Detail

Summary

• Symbol: Col10a1^tm1(cre)Haak
• Name: collagen, type X, alpha 1; targeted mutation 1, Haruhiko Akiyama
• MGI ID: MGI:5293313
• Synonyms: Col10a1-Cre
• Gene: Col10a1 Location: Chr10:34265977-34273081 bp, + strand Genetic Position: Chr10, 18.85 cM, cytoband B1-B3
• Alliance: Col10a1^tm1(cre)Haak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176952
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Col10a1^tm1(cre)Haak expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Col10a1 (MGI:88445)

• Mutation details: The targeting vector contained a 13.1 kb fragment of Col10a1 and an IRES-cre-pA sequence/Frt-flanked PGK-neo bovine pA cassette. Homologous recombination in G4 ES cells resulted in insertion of the vector sequence into the 3' UTR of the endogenous Col10a1 locus. Chimeras were subsequently bred to C57BL/6 mice. (J:176952)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Col10a1 (mouse) Summary of all recombinase alleles driven by Col10a1. Alliance mouse Col10a1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col10a1 Mutation: 28 strains or lines available

References

• Original: J:176952 Kim Y, et al., Generation of transgenic mice for conditional overexpression of Sox9. J Bone Miner Metab. 2011 Jan;29(1):123-9
• All: 5 reference(s)