Prkab2^tm1Grst
Targeted Allele Detail

Summary

• Symbol: Prkab2^tm1Grst
• Name: protein kinase, AMP-activated, beta 2 non-catalytic subunit; targeted mutation 1, Gregory R Steinberg
• MGI ID: MGI:5293372
• Synonyms: Prkab2^fl
• Gene: Prkab2 Location: Chr3:97565527-97581128 bp, + strand Genetic Position: Chr3, 42.25 cM
• Alliance: Prkab2^tm1Grst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167339
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• A loxP was inserted upstream of exon 2, and a floxed neo cassette was inserted downstream of exon 4. (J:167339)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkab2 Mutation: 29 strains or lines available

References

• Original: J:167339 Steinberg GR, et al., Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem. 2010 Nov 26;285(48):37198-209
• All: 8 reference(s)