Prkab1^tm1Grst
Targeted Allele Detail

Summary

• Symbol: Prkab1^tm1Grst
• Name: protein kinase, AMP-activated, beta 1 non-catalytic subunit; targeted mutation 1, Gregory R Steinberg
• MGI ID: MGI:5293373
• Synonyms: Prkab1^fl
• Gene: Prkab1 Location: Chr5:116151654-116162449 bp, - strand Genetic Position: Chr5, 56.1 cM, cytoband F
• Alliance: Prkab1^tm1Grst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176578
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP was inserted upstream of exon 2, and a loxP site flanked neomycin resistance gene cassette was inserted into of intron 4. (J:176578)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkab1 Mutation: 24 strains or lines available

References

• Original: J:176578 O'Neill HM, et al., AMP-activated protein kinase (AMPK) {beta}1{beta}2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16092-7
• All: 8 reference(s)