Fstl1^tm1.2Mvdh
Targeted Allele Detail

Summary

• Symbol: Fstl1^tm1.2Mvdh
• Name: follistatin-like 1; targeted mutation 1.2, Maurice JB van den Hoff
• MGI ID: MGI:5293374
• Synonyms: Fstl1^-
• Gene: Fstl1 Location: Chr16:37597417-37656878 bp, + strand Genetic Position: Chr16, 26.48 cM
• Alliance: Fstl1^tm1.2Mvdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176532
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination was employed to insert an Frt-flanked neo cassette followed by an loxP site after exon 2 of Fstl1 and another loxP site before exon 2. Chimeric males were crossed to FVB females, and the offspring were crossed to Flpe deleters to remove the neo cassette, and then crossed to CMV-cre transgenic animals to delete exon 2. (J:176532)

Expression

In Structures Affected by this Mutation:

20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fstl1 Mutation: 46 strains or lines available

References

• Original: J:176532 Sylva M, et al., The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. PLoS One. 2011;6(8):e22616
• All: 1 reference(s)