Tg(CEPHY141G6)4Hgc
Transgene Detail

Summary

• Symbol: Tg(CEPHY141G6)4Hgc
• Name: transgene insertion 4, Edward M Rubin
• MGI ID: MGI:5293441
• Synonyms: Tg(YAC141G6)4Hg, YAC 141G6, YAC 141G6 Line 4, YAC Lg 4
• Transgene: Tg(CEPHY141G6)4Hgc Location: unknown
• Alliance: Tg(CEPHY141G6)4Hgc page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CEPHY141G6)4Hgc expresses 4 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HLCS (3141)

  Hlcs	(MGI:894646)

  human

  PIGP (51227)

  Pigp	(MGI:1860433)

  human

  TTC3 (7267)

  Ttc3	(MGI:1276539)

  human

  VPS26C (10311)

  Vps26c

  (MGI:1206040)

• Mutation details: The transgene comprises a yeast artificial chromosome (YAC) from the CEPH Whole Genome MegaYAC Library carrying a 475-kb fragment of DNA from human Chromosome 21 containing the genes HLCS (holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)), PIGP (phosphatidylinositol glycan anchor biosynthesis, class P; formerly DSCR5), TTC3 (tetratricopeptide repeat domain 3) and DSCR3 (Down syndrome critical region gene 3). This transgenic line was shown by length-adjusted quantitative Southern blot analysis to bear a single copy of the YAC. (J:128897)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:128897 Smith DJ, et al., Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics. 1995 Jun 10;27(3):425-34
• All: 6 reference(s)