Tg(CEPHY152F7)12Hgc
Transgene Detail
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Symbol: |
Tg(CEPHY152F7)12Hgc |
Name: |
transgene insertion 12, Edward M Rubin |
MGI ID: |
MGI:5293446 |
Synonyms: |
152F7, Tg(YAC152F7)12Hgc, YAC 152F7, YAC 152F7 Line 12, YAC Lg 12 |
Transgene: |
Tg(CEPHY152F7)12Hgc Location: unknown
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Alliance: |
Tg(CEPHY152F7)12Hgc page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(CEPHY152F7)12Hgc expresses
4 genes
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
DYRK1A (1859) |
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human |
KCNJ6 (3763) |
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human |
TTC3 (7267) |
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human |
VPS26C (10311) |
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Mutation details: The transgene comprises a yeast artificial chromosome (YAC) from the CEPH Whole Genome MegaYAC Library carrying a 570-kb fragment of DNA from human Chromosome 21 containing the genes TTC3 (tetratricopeptide repeat domain 3), DSCR3 (Down syndrome critical region gene 3) and DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A). The potassium inwardly-rectifying channel, subfamily J, member 6 gene, KCNJ6 (also called GIRK2, KIR3.2 or HUM21ES123), which is present in this YAC, is expressed in the brain both in humans and in mice bearing the YAC as a transgene. This transgenic line was shown by length-adjusted quantitative Southern blot analysis to carry a single copy of the YAC.
(J:128897)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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Original: |
J:128897 Smith DJ, et al., Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics. 1995 Jun 10;27(3):425-34 |
All: |
7 reference(s) |
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