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Tg(CEPHY152F7)12Hgc
Transgene Detail
Summary
Symbol: Tg(CEPHY152F7)12Hgc
Name: transgene insertion 12, Edward M Rubin
MGI ID: MGI:5293446
Synonyms: 152F7, Tg(YAC152F7)12Hgc, YAC 152F7, YAC 152F7 Line 12, YAC Lg 12
Transgene: Tg(CEPHY152F7)12Hgc  Location: unknown  
Alliance: Tg(CEPHY152F7)12Hgc page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CEPHY152F7)12Hgc expresses 4 genes
 
Mutation detailsThe transgene comprises a yeast artificial chromosome (YAC) from the CEPH Whole Genome MegaYAC Library carrying a 570-kb fragment of DNA from human Chromosome 21 containing the genes TTC3 (tetratricopeptide repeat domain 3), DSCR3 (Down syndrome critical region gene 3) and DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A). The potassium inwardly-rectifying channel, subfamily J, member 6 gene, KCNJ6 (also called GIRK2, KIR3.2 or HUM21ES123), which is present in this YAC, is expressed in the brain both in humans and in mice bearing the YAC as a transgene. This transgenic line was shown by length-adjusted quantitative Southern blot analysis to carry a single copy of the YAC. (J:128897)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:128897 Smith DJ, et al., Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics. 1995 Jun 10;27(3):425-34
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory