Twf2^tm1Pla
Targeted Allele Detail

Summary

• Symbol: Twf2^tm1Pla
• Name: twinfilin actin binding protein 2; targeted mutation 1, Pekka Lappalainen
• MGI ID: MGI:5293453
• Synonyms: Twf-2a^-
• Gene: Twf2 Location: Chr9:106080307-106092586 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Twf2^tm1Pla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176349
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Modified isoform(s)) Mutation: Insertion Mutation details: Exon 1 was disrupted by the insertion of a neo cassette. Northern blot, RT-PCR, and western blot analysis confirmed the absence expression RNA and protein of the 2a isoform. RT-PCR confirmed the expression of the 2b isoform. (J:176349)

Generation of the Twf2^tm1Pla/ allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Twf2 Mutation: 31 strains or lines available

References

• Original: J:176349 Nevalainen EM, et al., Twinfilin-2a is dispensable for mouse development. PLoS One. 2011;6(8):e22894
• All: 2 reference(s)