Tmprss11d^tm1Bug
Targeted Allele Detail

Summary

• Symbol: Tmprss11d^tm1Bug
• Name: transmembrane protease, serine 11d; targeted mutation 1, Thomas H Bugge
• MGI ID: MGI:5293641
• Gene: Tmprss11d Location: Chr5:86450713-86521246 bp, - strand Genetic Position: Chr5, 43.56 cM
• Alliance: Tmprss11d^tm1Bug page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175364
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A MICER vector (MHPN265D14) was used to insert an inverted neo cassette, a TYR1-HPRT construct, and a genomic fragment containing exons 4 and 5, after exon 5 of the gene. This insertion introduces a frameshift mutation. RT-PCR analysis showed the expression of a mutant transcript containing the duplicated exons. (J:175364)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmprss11d Mutation: 34 strains or lines available

References

• Original: J:175364 Sales KU, et al., Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT. PLoS One. 2011;6(8):e23261
• All: 1 reference(s)