Glra1^tm2.1Geh
Targeted Allele Detail

Summary

• Symbol: Glra1^tm2.1Geh
• Name: glycine receptor, alpha 1 subunit; targeted mutation 2.1, Gregg E Homanics
• MGI ID: MGI:5293667
• Synonyms: alpha1(M287L)
• Gene: Glra1 Location: Chr11:55405065-55499024 bp, - strand Genetic Position: Chr11, 33.12 cM
• Alliance: Glra1^tm2.1Geh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177106
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting construct was designed to insert a frt-flanked neomycin (neo) resistance cassette downstream of exon 8 of the glycine receptor, alpha 1 subunit (Glra1) gene. Nucleotide substitutions (ATG to CTA) introduced in exon 8 resulted in the amino acid mutation M287L. Flp-mediated recombination removed the neo cassette. (J:177106)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Glra1 Mutation: 30 strains or lines available

References

• Original: J:177106 Homanics GE, Direct Data Submission 2011/10/27. MGI Direct Data Submission. 2011
• All: 3 reference(s)